Can one simply say „no“ to solipsism?

Simply say yes to NO? Nitric oxide (NO) sensor-based assessment of coronary endothelial function.

In 1980 Furchgott and Zawadzki published their observation on how removal of the endothelium abolishes acetylcholine-induced relaxation of vascular smooth muscle cells, which ignited a passionate search for an endothelium-derived vasorelaxing factor. Yet who would have thought in the beginning that the search was for a gas! Seven years later, Ignarro and co-workers identified nitric oxide (NO) ...

Can we just say NO to sickle cell anemia?

Say NO to insulin

H. pylori mobilizes cells elicobacter pylori infects the gastric track of more than half of the human population and is associated with an increased occurrence of invasive gastric cancers. On page 249, Churin et al. explain how this widespread bug turns tumors metastatic by corrupting a growth factor receptor. H H. pylori infection mobilizes gastric epithelial cells (right) by activating c-Met....

Say NO to hypoperfusion!

AUTOREGULATION is defined as the capacity of an organ or tissue to maintain a constant blood flow in the face of a change in perfusion pressure, while metabolism is unchanged. Under normal physiological conditions, large proximal arteries contribute little to the total resistance of a particular vascular bed. However, when atherosclerosis causes a conductance artery to narrow so that over 70% o...

Codeine: Time to Say "No".

Codeine has been prescribed to pediatric patients for many decades as both an analgesic and an antitussive agent. Codeine is a prodrug with little inherent pharmacologic activity and must be metabolized in the liver into morphine, which is responsible for codeine's analgesic effects. However, there is substantial genetic variability in the activity of the responsible hepatic enzyme, CYP2D6, and...